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UNC8153 TFA
CAS No. 2929304-61-8
UNC8153 TFA( —— )
Catalog No. M37355 CAS No. 2929304-61-8
UNC8153 TFA is a selective and potent NSD2 protein degrader with anticancer activity.UNC8153 TFA induces NSD2 degradation in MM.1S multiple myeloma cells and inhibits the proliferation of MM.1S cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 109 | Get Quote |
|
| 5MG | 217 | Get Quote |
|
| 10MG | 353 | Get Quote |
|
| 25MG | 564 | Get Quote |
|
| 50MG | 799 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameUNC8153 TFA
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NoteResearch use only, not for human use.
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Brief DescriptionUNC8153 TFA is a selective and potent NSD2 protein degrader with anticancer activity.UNC8153 TFA induces NSD2 degradation in MM.1S multiple myeloma cells and inhibits the proliferation of MM.1S cells.
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DescriptionUNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorHistone Methyltransferase
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Research Area——
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Indication——
Chemical Information
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CAS Number2929304-61-8
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Formula Weight697.7
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Molecular FormulaC35H38F3N5O7
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C(F)(F)F.O=C(NC1=CC=C(C=C1)C(=O)NCCCCCCN)C2=CC=C(C=C2)CN(C(=O)C3=CC=C4NC(=O)COC4=C3)C5CC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188. ?
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